Integrating multi-omics data, such as DNA methylation, mRNA expression, and microRNA (miRNA) expression, offers a comprehensive view of the biological mechanisms underlying disease. However, the high dimensionality and complex interactions among omics layers present major challenges for predictive modeling. We propose Multi-Omics integration with Tree-generated Graph Neural Network (MOTGNN), a novel and interpretable framework for binary disease classification. MOTGNN employs eXtreme Gradient Boosting (XGBoost) to perform omics-specific supervised graph construction, followed by modality-specific Graph Neural Networks (GNNs) for hierarchical representation learning, and a deep feedforward network for cross-omics integration. On three real-world disease datasets, MOTGNN outperforms state-of-the-art baselines by 5-10% in accuracy, ROC-AUC, and F1-score, and remains robust to severe class imbalance (e.g., 87.2% vs. 33.4% F1 on imbalanced data). The model maintains computational efficiency through sparse graphs (2.1-2.8 edges per node) and provides built-in interpretability, revealing both top-ranked biomarkers and the relative contributions of each omics modality. These results highlight MOTGNN's potential to improve both predictive accuracy and interpretability in multi-omics disease modeling.

Indoor gardening within sustainable buildings offers a transformative solution to urban food security and environmental sustainability. By 2030, urban farming, including Controlled Environment Agriculture (CEA) and vertical farming, is expected to grow at a compound annual growth rate (CAGR) of 13.2% from 2024 to 2030, according to market reports. This growth is fueled by advancements in Internet of Things (IoT) technologies, sustainable innovations such as smart growing systems, and the rising interest in green interior design. This paper presents a novel framework that integrates computer vision, machine learning (ML), and environmental sensing for the automated monitoring of plant health and growth. Unlike previous approaches, this framework combines RGB imagery, plant phenotyping data, and environmental factors such as temperature and humidity, to predict plant water stress in a controlled growth environment. The system utilizes high-resolution cameras to extract phenotypic features, such as RGB, plant area, height, and width while employing the Lag-Llama time series model to analyze and predict water stress. Experimental results demonstrate that integrating RGB, size ratios, and environmental data significantly enhances predictive accuracy, with the Fine-tuned model achieving the lowest errors (MSE = 0.420777, MAE = 0.595428) and reduced uncertainty. These findings highlight the potential of multimodal data and intelligent systems to automate plant care, optimize resource consumption, and align indoor gardening with sustainable building management practices, paving the way for resilient, green urban spaces.

The transition towards patient-centric healthcare necessitates a comprehensive understanding of patient journeys, which encompass all healthcare experiences and interactions across the care spectrum. Existing healthcare data systems are often fragmented and lack a holistic representation of patient trajectories, creating challenges for coordinated care and personalized interventions. Patient Journey Knowledge Graphs (PJKGs) represent a novel approach to addressing the challenge of fragmented healthcare data by integrating diverse patient information into a unified, structured representation. This paper presents a methodology for constructing PJKGs using Large Language Models (LLMs) to process and structure both formal clinical documentation and unstructured patient-provider conversations. These graphs encapsulate temporal and causal relationships among clinical encounters, diagnoses, treatments, and outcomes, enabling advanced temporal reasoning and personalized care insights. The research evaluates four different LLMs, such as Claude 3.5, Mistral, Llama 3.1, and Chatgpt4o, in their ability to generate accurate and computationally efficient knowledge graphs. Results demonstrate that while all models achieved perfect structural compliance, they exhibited variations in medical entity processing and computational efficiency. The paper concludes by identifying key challenges and future research directions. This work contributes to advancing patient-centric healthcare through the development of comprehensive, actionable knowledge graphs that support improved care coordination and outcome prediction.

Chronological Overview Table of Key Advancements in Graph-Based Neural Networks V. PROBLEM STATEMENT The key issue addressed in this research is the limited understanding of the geometric properties of neural networks, which affects both their interpretability and efficiency. The complexity of the network's geometry influences its learning process, impacting both optimization and generalization. This problem is significant because better geometric interpretations of neural networks can lead to improvements in various tasks, such as classification, optimization, and shape representation. A central challenge is the lack of understanding of the structure of data manifolds that influence how neural networks perform complex tasks. The geometric structures governing neural networks include the relationships between network layers, activation functions, and data manifolds, which directly impact performance in tasks like classification and optimization. The association between neural networks and geometric structures remains under-explored, and improving this understanding could result in more effective algorithms for managing complex data and optimizing performance. Additionally, the graph structure of neural networks plays a crucial role in their predictive performance, yet there is limited knowledge of how this structure influences accuracy. Optimizing the graph structure of neural networks could enhance their efficiency and generalizability across different datasets, which is also important for future hardware advancements. Ultimately, improving the geometric and structural comprehension of neural networks can lead to more robust and versatile models capable of performing across diverse tasks and platforms.

Sparse autoencoders (SAEs) are an increasingly popular technique for interpreting the internal representations of transformers. In this paper, we apply SAEs to 'interpret' random transformers, i.e., transformers where the parameters are sampled IID from a Gaussian rather than trained on text data. We find that random and trained transformers produce similarly interpretable SAE latents, and we confirm this finding quantitatively using an open-source auto-interpretability pipeline. Further, we find that SAE quality metrics are broadly similar for random and trained transformers. We find that these results hold across model sizes and layers. We discuss a number of number interesting questions that this work raises for the use of SAEs and auto-interpretability in the context of mechanistic interpretability.

This paper explores the relatively underexplored application of Positive Unlabeled (PU) Learning and Negative Unlabeled (NU) Learning in the cybersecurity domain. While these semi-supervised learning methods have been applied successfully in fields like medicine and marketing, their potential in cybersecurity remains largely untapped. The paper identifies key areas of cybersecurity--such as intrusion detection, vulnerability management, malware detection, and threat intelligence--where PU/NU learning can offer significant improvements, particularly in scenarios with imbalanced or limited labeled data. We provide a detailed problem formulation for each subfield, supported by mathematical reasoning, and highlight the specific challenges and research gaps in scaling these methods to real-time systems, addressing class imbalance, and adapting to evolving threats. Finally, we propose future directions to advance the integration of PU/NU learning in cybersecurity, offering solutions that can better detect, manage, and mitigate emerging cyber threats.

This paper explores the application of Positive-Unlabeled (PU) learning for enhanced Distributed Denial-of-Service (DDoS) detection in cloud environments. Utilizing the $\texttt{BCCC-cPacket-Cloud-DDoS-2024}$ dataset, we implement PU learning with four machine learning algorithms: XGBoost, Random Forest, Support Vector Machine, and Na\"{i}ve Bayes. Our results demonstrate the superior performance of ensemble methods, with XGBoost and Random Forest achieving $F_{1}$ scores exceeding 98%. We quantify the efficacy of each approach using metrics including $F_{1}$ score, ROC AUC, Recall, and Precision. This study bridges the gap between PU learning and cloud-based anomaly detection, providing a foundation for addressing Context-Aware DDoS Detection in multi-cloud environments. Our findings highlight the potential of PU learning in scenarios with limited labeled data, offering valuable insights for developing more robust and adaptive cloud security mechanisms.

In many real-world continuous action domains, human agents must decide which actions to attempt and then execute those actions to the best of their ability. However, humans cannot execute actions without error. Human performance in these domains can potentially be improved by the use of AI to aid in decision-making. One requirement for an AI to correctly reason about what actions a human agent should attempt is a correct model of that human's execution error, or skill. Recent work has demonstrated successful techniques for estimating this execution error with various types of agents across different domains. However, this previous work made several assumptions that limit the application of these ideas to real-world settings. First, previous work assumed that the error distributions were symmetric normal, which meant that only a single parameter had to be estimated. In reality, agent error distributions might exhibit arbitrary shapes and should be modeled more flexibly. Second, it was assumed that the execution error of the agent remained constant across all observations. Especially for human agents, execution error changes over time, and this must be taken into account to obtain effective estimates. To overcome both of these shortcomings, we propose a novel particle-filter-based estimator for this problem. After describing the details of this approximate estimator, we experimentally explore various design decisions and compare performance with previous skill estimators in a variety of settings to showcase the improvements. The outcome is an estimator capable of generating more realistic, time-varying execution skill estimates of agents, which can then be used to assist agents in making better decisions and improve their overall performance.

Global Positioning System (GPS) navigation provides accurate positioning with global coverage, making it a reliable option in open areas with unobstructed sky views. However, signal degradation may occur in indoor spaces and urban canyons. In contrast, Inertial Measurement Units (IMUs) consist of gyroscopes and accelerometers that offer relative motion information such as acceleration and rotational changes. Unlike GPS, IMUs do not rely on external signals, making them useful in GPS-denied environments. Nonetheless, IMUs suffer from drift over time due to the accumulation of errors while integrating acceleration to determine velocity and position. Therefore, fusing the GPS and IMU is crucial for enhancing the reliability and precision of navigation systems in autonomous vehicles, especially in environments where GPS signals are compromised. To ensure smooth navigation and overcome the limitations of each sensor, the proposed method fuses GPS and IMU data. This sensor fusion uses the Unscented Kalman Filter (UKF) Bayesian filtering technique. The proposed navigation system is designed to be robust, delivering continuous and accurate positioning critical for the safe operation of autonomous vehicles, particularly in GPS-denied environments. This project uses KITTI GNSS and IMU datasets for experimental validation, showing that the GNSS-IMU fusion technique reduces GNSS-only data's RMSE. The RMSE decreased from 13.214, 13.284, and 13.363 to 4.271, 5.275, and 0.224 for the x-axis, y-axis, and z-axis, respectively. The experimental result using UKF shows promising direction in improving autonomous vehicle navigation using GPS and IMU sensor fusion using the best of two sensors in GPS-denied environments.

Wind speed is a powerful source of renewable energy, which can be used as an alternative to the non-renewable resources for production of electricity. Renewable sources are clean, infinite and do not impact the environment negatively during production of electrical energy. However, while eliciting electrical energy from renewable resources viz. solar irradiance, wind speed, hydro should require special planning failing which may result in huge loss of labour and money for setting up the system. In this paper, we discuss four deep recurrent neural networks viz. Stacked Stateless LSTM, Stacked Stateless GRU, Stacked Stateful LSTM and Statcked Stateful GRU which will be used to predict wind speed on a short-term basis for the airport sites beside two campuses of Mississippi State University. The paper does a comprehensive analysis of the performance of the models used describing their architectures and how efficiently they elicit the results with the help of RMSE values. A detailed description of the time and space complexities of the above models has also been discussed.